Pathophysiology of atopic dermatitis: Clinical implications
نویسندگان
چکیده
منابع مشابه
Atopic Dermatitis: From Pathophysiology to Diagnostic Approach
Atopic eczema/dermatitis syndrome (AEDS) is a chronic inflammatory skin disease, very common in childhood (1). The prevalence of AEDS is estimated to 15–30% in children and 2–10% in adults while the incidence has shown a 2to 3-fold increase in the past 3 decades in developed countries (2). This results in a significant socio-economic impact, that in the United States was estimated in a range fr...
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Pruritus is an essential feature of atopic dermatitis with a high impact on the quality of life. Although the pathophysiology of atopic dermatitis itch is not fully understood, recent studies have demonstrated that a variety of mechanisms contribute to the induction and maintenance of the symptom. For example, an increased number of cutaneous nerve fibers and neuropeptides were identified in at...
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Atopic Dermatitis (AD) is a common inflammatory, pruritic skin disorder. It is a chronic disease with often relapse. Several factors including genetic predisposition, allergies to specific foods, irritant chemicals, and aeroallergens are thought to be the cause of AD. Diagnosis is difficult, and often occurs after ruling out other disorders with a clinical presentation resembling atopic dermati...
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Atopic dermatitis has a significant impact on both the pediatric and adult population worldwide, which has triggered extensive research on the topic. However, various limitations have created difficulties both in making accurate diagnoses and effectively managing atopic dermatitis patients. This review summarizes the current knowledge in the field, providing an overview of the pathophysiology, ...
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Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles in atopic inflammation. The expression of IL-4 and IL-13 as well as type 2 chemokines such a...
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ژورنال
عنوان ژورنال: Allergy and Asthma Proceedings
سال: 2019
ISSN: 1088-5412
DOI: 10.2500/aap.2019.40.4202